Analysis of social and economic aspects of using prolonged forms of opioid analgesics for the treatment of chronic pain syndrome in cancer patients

Background . The therapy of chronic pain in cancer patients is a highly topical issue for the modern health care system. Intense syndrome involves prescription strong opioid analgesics (ОА), most which are classified as narcotic drugs and under strict governmental control. In this situation, increasing use that equivalent dosages to morphine do not require special drug may increase availability relief will be less associated with addiction. Objective : analyze regulatory, organizational, clinical, economic criteria determine choice influence ОА adequate (CPS). Material methods. article determines legal regulatory framework regulating sphere providing ОА, presents an expert evaluation existing barriers limit treatment, shows ways solve these issues. We present results original Russian clinical study evaluating prolonged forms (tapentadol morphine) treatment moderate severe CPS healthcare evidence comparative efficiency safety consideration analyzed. costs provide 1 year analgesia intensive oncology compared. Results Differences status opioids, including requirements prescribing, storage, record keeping, use, were shown affect medication. According systematic review meta-analysis randomized controlled trials, no differences found any outcomes studied tapentadol groups: frequency achieving control – risk ratio (RR) 0.88 (95% confidence interval (CI) 0.78–1.00), using emergency (additional) RR 1.16 CI 0.95–1.42), gastrointestinal adverse events 0.82 0.60–1.12). This suggests comparable drugs. difference average cost patient course between was 17,653.02 rubles (–16.8%). Additional funds released case treating cohort 100 instead made 1,765,301.96 rubles, means 20 more could treated year. Conclusion effective non-invasive particular) have restrictions imposed by documents on availability, well reduce compared daily doses morphine.